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CUGBP Elav-like family member 4

From Wikipedia, the free encyclopedia
CELF4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCELF4, BRUNOL-4, BRUNOL4, CELF-4, CUGBP, Elav-like family member 4, CUGBP Elav-like family member 4
External IDsOMIM: 612679; MGI: 1932407; HomoloGene: 23202; GeneCards: CELF4; OMA:CELF4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001025087
NM_001025088
NM_001025089
NM_020180
NM_001330603

RefSeq (protein)
Location (UCSC)n/aChr 18: 25.48 – 25.75 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

CUGBP Elav-like family member 4 (CELF4) also known as bruno-like protein 4 (BRUNOL4) is a protein that in humans is encoded by the CELF4 gene.[4][5]

Function

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Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. Several transcript variants encoding different isoforms have been found for this gene, but their full-length nature has not been determined yet.[5]

References

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  1. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024268Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ Good PJ, Chen Q, Warner SJ, Herring DC (Oct 2000). "A family of human RNA-binding proteins related to the Drosophila Bruno translational regulator". J Biol Chem. 275 (37): 28583–92. doi:10.1074/jbc.M003083200. PMID 10893231.
  5. ^ a b "Entrez Gene: BRUNOL4 bruno-like 4, RNA binding protein (Drosophila)".
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Further reading

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